VERFAHREN ZUR HERSTELLUNG VON PROSTAGLANDIN E

To produce a prostaglandin E in a short time and in a high yield while minimizing the formation of isomers. A process for producing a prostaglandin E represented by general formula (I) wherein A represents an arbitrary group not participating in the reaction; B represents vinylene or ethynylene; R a...

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Bibliographische Detailangaben
Hauptverfasser:	GOTO, JUN, AMANO, TAKEHIRO, KAMEO, KAZUYA, MUTOH, MASARU, TANAMI, TOHRU, SATO, FUMIE, ONO, NAOYA
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	To produce a prostaglandin E in a short time and in a high yield while minimizing the formation of isomers. A process for producing a prostaglandin E represented by general formula (I) wherein A represents an arbitrary group not participating in the reaction; B represents vinylene or ethynylene; R and R may be the same or different from each other and each represents hydrogen or a protective group for a hydroxyl group; and R and R represent each an arbitrary group not participating in the reaction, which comprises reacting an allyl ester of a prostaglandin E represented by general formula (II) wherein R and R may be the same or different from each other and each represents hydrogen or lower alkyl; R represents hydrogen, lower alkyl, alkenyl or aryl; and R , R , R , R , A and B are each as defined above, with one or two compounds selected from the group consisting of bases and formic acid in the presence of a complex compound or a complex salt of 0-valent or divalent palladium atom.