SCREENINGTEST FÜR DEN NACHWEIS VON DNA-BINDENDEN MOLEKÜLEN

The present invention provides a method for inhibiting the binding of a DNA-binding protein to duplex DNA, whereby a small molecule is brought into contact with a duplex DNA which contains a test sequence adjacent to a screening sequence, where the DNA binding protein is effective to bind to the scr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	EDWARDS, CYNTHIA, A, CANTOR, CHARLES, R, ANDREWS, BETH, M
Format:	Patent
Sprache:	ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a method for inhibiting the binding of a DNA-binding protein to duplex DNA, whereby a small molecule is brought into contact with a duplex DNA which contains a test sequence adjacent to a screening sequence, where the DNA binding protein is effective to bind to the screening sequence with a binding affinity that is substantially independent of said test sequence, further where the binding of said small molecule to the test sequence inhibits the binding of the protein to the screening sequence.