MANGAN-KOMPLEXE MIT STICKSTOFF ENTHALTENDEN MAKROZYKLISCHEN LIGANDEN, WIRKSAM ALS SUPEROXIDDISMUTASEKATALYSATOREN

The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: wherein R, R min , R1, R min 1, R2, R min 2, R3, R min 3, R4, R min 4, R5, R min 5, R6, R min 6, R7, R min 7, R8, R min 8, R9, and R min 9 and X, Y, Z and n are as defined herei...

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Bibliographische Detailangaben
Hauptverfasser:	LENNON, PATRIC, JAMES, NEUMAN, WILLIAM, LOJDA, MODAK, ANIL, SHRIKRISHNA, RILEY, DENNIS, PATRICK, ASTON, KARL, WILLIAM, WEISS, RANDY, HERMAN
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: wherein R, R min , R1, R min 1, R2, R min 2, R3, R min 3, R4, R min 4, R5, R min 5, R6, R min 6, R7, R min 7, R8, R min 8, R9, and R min 9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.