ISOLIERUNG VON FETALEN ZELLEN AUS MÜTTERLICHEM BLUT ZUR AUSFÜHRUNG VON PRÄNATALER DIAGNOSTIK

PCT No. PCT/AU89/00517 Sec. 371 Date Jul. 3, 1991 Sec. 102(e) Date Jul. 3, 1991 PCT Filed Nov. 29, 1989 PCT Pub. No. WO90/06509 PCT Pub. Date Jun. 14, 1990.This invention relates to a method for the isolation of trophoblast (placental) cells from the blood of a pregnant mammal so as to provide the e...

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Hauptverfasser:	MUELLER, UTZ, WALTER, HAWES, CATHERINE, STELLA
Format:	Patent
Sprache:	ger
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	PCT No. PCT/AU89/00517 Sec. 371 Date Jul. 3, 1991 Sec. 102(e) Date Jul. 3, 1991 PCT Filed Nov. 29, 1989 PCT Pub. No. WO90/06509 PCT Pub. Date Jun. 14, 1990.This invention relates to a method for the isolation of trophoblast (placental) cells from the blood of a pregnant mammal so as to provide the essential starting material, namely cells derived from the fetus, to enable genetic and/or biochemical information about the fetus to be obtained. In particular, this invention relates to the use of monoclonal antibodies specific for membrane protein markers on mammalian trophoblasts to isolate trophoblast cells from maternal blood. These cells may then be used to obtain fetal genetic and/or biochemical information early in pregnancy. The present invention is particularly relevant for detecting human fetal abnormalities.