VERFAHREN FÜR DIE SYNTHESE VON 2,6-DICHLOR-5- FLUORNICOTINSÄURE UND 2,6-DICHLOR-5- FLUORNICOTINOYLCHLORID
An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis...
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| Format: | Patent |
| Sprache: | ger |
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| Zusammenfassung: | An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid. |
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