VERFAHREN ZUR HERSTELLUNG VON ZWISCHENPRODUKTEN FÜR DIE ANTIGESTAGENSYNTHESE (ONAPRISTONSYNTHESE)

VERFAHREN ZUR HERSTELLUNG VON ZWISCHENPRODUKTEN FÜR DIE ANTIGESTAGENSYNTHESE (ONAPRISTONSYNTHESE)

A process for the preparation of intermediates of the general formula III in which Z, R and R have the meaning indicated in the description, is described and entails a compound of the general formula II in which R and Z have the meaning indicated in formula III, being reacted with a compound of the...

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Bibliographische Detailangaben
Hauptverfasser: ROHDE, RALPH, OTTOW, ECKARD, NEEF, GUENTER
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Zusammenfassung:A process for the preparation of intermediates of the general formula III in which Z, R and R have the meaning indicated in the description, is described and entails a compound of the general formula II in which R and Z have the meaning indicated in formula III, being reacted with a compound of the formula (Hal = halogen) with the addition of a Cu(I) salt. These intermediates are suitable for the preparation of antigestagens (especially Onapristone, EP-A 0 129 499).