VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON SALZEN DER 4-AMINO-1-HYDROXYBUTYLIDEN-1,1- BISPHOSPHONSÄURE

An improved process is described for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP)or salts thereof which comprises: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and PCl3 in the presence of methanesulfonic acid; (b) contacting the mixture from Step...

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1. Verfasser:	KIECZYKOWSKI, GERARD R
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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creator	KIECZYKOWSKI, GERARD R
description	An improved process is described for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP)or salts thereof which comprises: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and PCl3 in the presence of methanesulfonic acid; (b) contacting the mixture from Step (a) with an aqueous hydrolysis mixture, wherein the pH is maintained in the range of 4 to 10 during the contacting; and (c) recovering said 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof. s
format	Patent
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(b) contacting the mixture from Step (a) with an aqueous hydrolysis mixture, wherein the pH is maintained in the range of 4 to 10 during the contacting; and (c) recovering said 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof. s</description><edition>6</edition><language>ger</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1995</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19951015&DB=EPODOC&CC=AT&NR=E128470T1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19951015&DB=EPODOC&CC=AT&NR=E128470T1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIECZYKOWSKI, GERARD R</creatorcontrib><title>VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON SALZEN DER 4-AMINO-1-HYDROXYBUTYLIDEN-1,1- BISPHOSPHONSÄURE</title><description>An improved process is described for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP)or salts thereof which comprises: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and PCl3 in the presence of methanesulfonic acid; (b) contacting the mixture from Step (a) with an aqueous hydrolysis mixture, wherein the pH is maintained in the range of 4 to 10 during the contacting; and (c) recovering said 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof. s</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1995</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNikEKwjAQRbtxIeod4t6A0YJuUzs1gZjITFJsN6VIdCNaqEfwZl7MCh7AxefxeH-cXEvADIgAPRAbpJAKwbI6IFOA5MGYYPesdJaRNPWQckCWcnnQ1nHBVZWjO1VZ8JXROVguFoKzTNNRue8svV8BYZqMLu2tj7MfJ8m8AL9TPHaPJvZde473-GykB7Happul92L9z-cDf1w3BQ</recordid><startdate>19951015</startdate><enddate>19951015</enddate><creator>KIECZYKOWSKI, GERARD R</creator><scope>EVB</scope></search><sort><creationdate>19951015</creationdate><title>VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON SALZEN DER 4-AMINO-1-HYDROXYBUTYLIDEN-1,1- BISPHOSPHONSÄURE</title><author>KIECZYKOWSKI, GERARD R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ATE128470TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>ger</language><creationdate>1995</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>KIECZYKOWSKI, GERARD R</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KIECZYKOWSKI, GERARD R</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON SALZEN DER 4-AMINO-1-HYDROXYBUTYLIDEN-1,1- BISPHOSPHONSÄURE</title><date>1995-10-15</date><risdate>1995</risdate><abstract>An improved process is described for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP)or salts thereof which comprises: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and PCl3 in the presence of methanesulfonic acid; 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subjects	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY METALLURGY ORGANIC CHEMISTRY
title	VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON SALZEN DER 4-AMINO-1-HYDROXYBUTYLIDEN-1,1- BISPHOSPHONSÄURE
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