VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON SALZEN DER 4-AMINO-1-HYDROXYBUTYLIDEN-1,1- BISPHOSPHONSÄURE

VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON SALZEN DER 4-AMINO-1-HYDROXYBUTYLIDEN-1,1- BISPHOSPHONSÄURE

An improved process is described for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP)or salts thereof which comprises: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and PCl3 in the presence of methanesulfonic acid; (b) contacting the mixture from Step...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
1. Verfasser: KIECZYKOWSKI, GERARD R
Format: Patent
Sprache:ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An improved process is described for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP)or salts thereof which comprises: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and PCl3 in the presence of methanesulfonic acid; (b) contacting the mixture from Step (a) with an aqueous hydrolysis mixture, wherein the pH is maintained in the range of 4 to 10 during the contacting; and (c) recovering said 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof. s