TETRAHYDROISOCHINOLIN-2-YL-DERIVATE ALS THROMBOXAN A2-ANTAGONISTEN

The invention provides compounds of the formula (I): and salts thereof; wherein A is a group NR SO2 or SO2NR ; R is an acyclic hydrocarbon group having from 1 to 4 linear carbon atoms; R is a bond or an acyclic hydrocarbon group having from 1 to 3 linear carbon atoms, provided that the total number of linear carbon atoms in R and R taken together does not exceed four and that the carbon atom in R which is adjacent to the isoquinoline ring nitrogen atom is saturated; the group is a monocyclic group having between three and seven ring members and containing up to three heteroatoms; Y is CO2H or a group hydrolysable to CO2H; R is phenyl optionally substituted by one or more substituents chosen from the group comprising halogen, C1-4alkyl, C1-6acyl, C1-4alkoxy, nitro and trifluoromethyl; R is hydrogen or one or more C1-4alkyl substituents located at the 1, 3 and 4 positions of the isoquinoline ring; and R is hydrogen or C1-6alkyl. Also provided are compositions containing the compounds of the formula (I), a process for their preparation and their use as thromboxane A2 antagonists.