NIKOTINSAEUREDERIVATE VON GLUKOSAMIN, VERFAHREN ZU IHRER HERSTELLUNG UND DIE SIE ENTHALTENDEN PHARMAZEUTISCHEN ZUSAMMENSETZUNGEN

NIKOTINSAEUREDERIVATE VON GLUKOSAMIN, VERFAHREN ZU IHRER HERSTELLUNG UND DIE SIE ENTHALTENDEN PHARMAZEUTISCHEN ZUSAMMENSETZUNGEN

The nicotinic derivatives of glucosamine, particularly N-nicotinoyl-glucosamine tetranicotinate are described as having anti-lipolitic, hypocholesterolemizing and antiaterogenic activities, at an equal or higher level than those of nicotinic acid, without the objectionable side effects shown by the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MURMANN, WALTER, PONCHIROLI, OSVALDO
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:The nicotinic derivatives of glucosamine, particularly N-nicotinoyl-glucosamine tetranicotinate are described as having anti-lipolitic, hypocholesterolemizing and antiaterogenic activities, at an equal or higher level than those of nicotinic acid, without the objectionable side effects shown by the acid. To prepare the compounds of the invention, nicotinoyl chloride hydrochloride and glucosamine hydrochloride are reacted in an organic solvent at a temperature of between 40 DEG C. and 120 DEG C.