VERFAHREN ZUR HERSTELLUNG VON KREBSVAKZINEN

Cancer vaccines are obtained by treating tumour cells or fibroblasts with a complex of DNA coding for an immunostimulating polypeptide, and of a DNA-binding substance, e.g. polylysine, which is preferably conjugated with transferrin. The complex also contains a conjugate of DNA-binding substance and...

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Bibliographische Detailangaben
Hauptverfasser: COTTEN MATTHEW DR, ZATLOUKAL KURT DR, SCHMIDT WALTER DR, BIRNSTIEL MAX L. DR, WAGNER ERNST DR
Format: Patent
Sprache:ger
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Zusammenfassung:Cancer vaccines are obtained by treating tumour cells or fibroblasts with a complex of DNA coding for an immunostimulating polypeptide, and of a DNA-binding substance, e.g. polylysine, which is preferably conjugated with transferrin. The complex also contains a conjugate of DNA-binding substance and an adenovirus. The adenovirus has at least one E4 defect or one E1a defect in combination with other gene defects.