PIPERAZIN-DERIVATE UND VERFAHREN ZUR HERSTELLUNG DERSELBEN

PIPERAZIN-DERIVATE UND VERFAHREN ZUR HERSTELLUNG DERSELBEN

The invention relates to a new and improved process for the preparation of 8-{4-[4-(2-pyrimidinyl)--1- piperazinyl]-butyl}-8-aza-spiro[4.5]decane-7,9--dione of the Formula I < IMAGE > and pharmaceutically acceptable acid addition salts thereof, which comprises hydrogenating a compound of the g...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GREGOR LIVIA, BUDAI ZOLTAN . DR, TAJTHY EVA JUDIT, REITER KLARA . DR, MEZEI TIBOR
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a new and improved process for the preparation of 8-{4-[4-(2-pyrimidinyl)--1- piperazinyl]-butyl}-8-aza-spiro[4.5]decane-7,9--dione of the Formula I < IMAGE > and pharmaceutically acceptable acid addition salts thereof, which comprises hydrogenating a compound of the general Formula II < IMAGE > (wherein A stands for -C IDENTICAL C- or CH=CH-) and, if desired, converting the compound of the Formula I thus obtained into a pharmaceuticaily acceptable acid additfon salt thereof. The compound of the Formula I is a known anxioselective agent. The invention also relates to intermediates of Formula II used in the above process and a method for the preparation thereof. These compounds also have anxioselective action.