Process for the preparation of 1-(2-(5- [dimethylaminomethyl]-2-[furylmethylthio]ethyl))amino-1- (methylamino)-2-nitroethylene hydrochloride

Process for the preparation of 1-(2-(5- [dimethylaminomethyl]-2-[furylmethylthio]ethyl))amino-1- (methylamino)-2-nitroethylene hydrochloride

Benzodiazocines corresponding to the formula are converted to benzodiazepines corresponding to the formula of claim 1 by subjecting the benzodiazocine (a) if it is halogen-substituted in the 3-position to a thermal treatment which may also take place in the presence of a nucleophilic agent for the r...

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Bibliographische Detailangaben
Hauptverfasser: STUHMER WERNER DR, BUDDEN RENKE DR, FUNKE SIEGFRIED DR, LIEPMANN HANS-GUNTHER DR, HUSCHENS ROLF DR, MILKOWSKI WOLFGANG DR, ZEUGNER HORST DR
Format: Patent
Sprache:eng ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Benzodiazocines corresponding to the formula are converted to benzodiazepines corresponding to the formula of claim 1 by subjecting the benzodiazocine (a) if it is halogen-substituted in the 3-position to a thermal treatment which may also take place in the presence of a nucleophilic agent for the reaction or (b) if the 3-position is hydroxy substituted to treatment with a Lewis acid which is a chlorinating or brominating agent. Whenever the diazepine obtained as the final product has a 2-halogenomethyl group it may then be converted to benzodiazepine which is otherwise substituted in the 2-position.