VERFAHREN ZUR HERSTELLUNG VON 5-BROM- ODER JOD-6,9ALPHA-OXIDO-PROSTAGLANDINDERIVATEN

The invention concerns a new process for the preparation of 5-halo-6,9 alpha -oxido-prostaglandin derivatives of the general formula II (II) wherein R1 represents a hydrogen atom, an alkyl group optionally substituted by aryl, amino, hydroxyl or a halogen atom, an equivalent of a pharmaceutically ac...

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Bibliographische Detailangaben
Hauptverfasser:	REDEY LASZLO.DR, KOVACS VERA, SZAMOS AGNES, SZEBENYI ENIKOE.DR
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY ELECTROLYTIC OR ELECTROPHORETIC PROCESSES ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTIONOF COMPOUNDS OR NON-METALS HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention concerns a new process for the preparation of 5-halo-6,9 alpha -oxido-prostaglandin derivatives of the general formula II (II) wherein R1 represents a hydrogen atom, an alkyl group optionally substituted by aryl, amino, hydroxyl or a halogen atom, an equivalent of a pharmaceutically acceptable organic or inorganic cation or a conventional hydroxyl protecting group; R2 represents a hydrogen atom, a hydroxyl group or a conventionally protected hydroxyl group; R3 is a hydrogen atom or a lower alkyl group; R4 represents a hydrogen atom or a conventional hydroxyl protecting group; R5 stands for a straight or branched chained alkyl group, optionally containing hetero atom(s) and optionally substituted by a substituted or unsubstituted aryl group, and X stands for a halogen atom, which comprises subsjecting prostaglandin F2 alpha derivatives of the general formula I (I)