VERFAHREN ZUR HERSTELLUNG VON PROTEINEN

Production of proteins from pro-proteins comprises contacting a pro-protein solution with a protease and a solid support that has a higher affinity for the proteins than for the pro-protein or its functionally inactive degradation products, whereby the pro-protein is proteolytically cleaved to form...

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Bibliographische Detailangaben
Hauptverfasser:	DORNER FRIEDRICH, FISCHER BERNHARD, MITTERER ARTUR DR, EIBL JOHANN DR
Format:	Patent
Sprache:	ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Production of proteins from pro-proteins comprises contacting a pro-protein solution with a protease and a solid support that has a higher affinity for the proteins than for the pro-protein or its functionally inactive degradation products, whereby the pro-protein is proteolytically cleaved to form the protein, which is selectively separated by adsorption on the solid support. Also claimed are: (1) a hirudin or a hirudin fragment or derivative coupled to a solid support; (2) a protein complex produced by the above process, comprising a protein adsorbed on a solid carrier, and (3) an apparatus for carrying out the above process, comprising a container containing a protease directly connected to a container containing a solid support.