VERFAHREN ZUR HERSTELLUNG NEUER 1-(HYDROXYSTYRYL)-5H-2,3-BENZODIAZEPIN-DERIVATE

This invention relates to new 1-(hydroxystyryl)-5H-2,3-benzodiazepine derivatives of the general formula (I) and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, (I) wherein R stands for a hydrogen or halogen atom, or a C1-4 alkoxy group, R1 r...

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Hauptverfasser:	HELTAI KRISZTINA DR, HAMORI TAMAS, ZOLYOMI GABOR . DR, POLGARI ISTVAN DR, SAROSSY JUDIT, LANG TIBOR . DR, KUHAR MARIA, LANG ZSUZSANNA DR, MORAVCSIK IMRE, RABLOCZKY GYOERGY DR, KOROESI JENOE . DR, ELEKES ISTVAN DR
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to new 1-(hydroxystyryl)-5H-2,3-benzodiazepine derivatives of the general formula (I) and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, (I) wherein R stands for a hydrogen or halogen atom, or a C1-4 alkoxy group, R1 represents a hydrogen atom or a C1-4 alkyl group, R2 and R3 are identical and denote a C1-4 alkyl group, or combined they denote a methylene group. The compounds of the general formula (I) possess valuable positive inotropic (cardiotonic) potency, are capable to increase the myocardiac contractile force (heart performance in cardiac insufficiency), thus they can be applied in the therapy of chronic heart failure and coronary ailments.