Mixture which is suitable for direct tableting and contains as essential components amoxicillin trihydrate and the calcium salt of clavulanic acid, and process for preparing this mixture
The invention proposes a mixture which is suitable for direct tableting and which contains as essential components amoxicillin trihydrate and the calcium salt of clavulanic acid, which is characterized in that amoxicillin trihydrate is in the form of an agglomerate and the mixture has an average par...
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Format: | Patent |
Sprache: | eng ; ger |
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Zusammenfassung: | The invention proposes a mixture which is suitable for direct tableting and which contains as essential components amoxicillin trihydrate and the calcium salt of clavulanic acid, which is characterized in that amoxicillin trihydrate is in the form of an agglomerate and the mixture has an average particle size of 100-800 μm, preferably of 200-600 μm, with the following particle size distribution: 1000 μm: max. 15 preferably: max. 10 >2000 μm: max. 0.1 and a density of 0.3-0.8, preferably of 0.4-0.6, and as an angle of repose of |
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