Process for the preparation of excipient-free agglomerates of beta-lactam antibiotics

The invention proposes excipient-free agglomerates of β-lactam antibiotics which are suitable for direct tableting and which are characterized in that the agglomerates have an average volume-based particle size of 200-1 000 μm with the following particle size distribution: 1000 μm: max. 30% >2000...

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Hauptverfasser:	RANEBURGER JOHANNES MAG, ZEISL ERICH DR
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	RANEBURGER JOHANNES MAG ZEISL ERICH DR
description	The invention proposes excipient-free agglomerates of β-lactam antibiotics which are suitable for direct tableting and which are characterized in that the agglomerates have an average volume-based particle size of 200-1 000 μm with the following particle size distribution: 1000 μm: max. 30% >2000 μm: max. 0.5% and an apparent density of from 0.4 to 0.8 g/ml. These agglomerates are prepared by making a paste of the active ingredients with a liquid, and extruding through a twin screw extruder and drying.
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These agglomerates are prepared by making a paste of the active ingredients with a liquid, and extruding through a twin screw extruder and drying.</description><edition>7</edition><language>eng ; ger</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010125&DB=EPODOC&CC=AT&NR=407214B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010125&DB=EPODOC&CC=AT&NR=407214B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RANEBURGER JOHANNES MAG</creatorcontrib><creatorcontrib>ZEISL ERICH DR</creatorcontrib><title>Process for the preparation of excipient-free agglomerates of beta-lactam antibiotics</title><description>The invention proposes excipient-free agglomerates of β-lactam antibiotics which are suitable for direct tableting and which are characterized in that the agglomerates have an average volume-based particle size of 200-1 000 μm with the following particle size distribution: <100 μm: 1 - 30% 100 - 500 μm: 10 - 80% 500 - 1000 μm: 10 - 80% >1000 μm: max. 30% >2000 μm: max. 0.5% and an apparent density of from 0.4 to 0.8 g/ml. 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subjects	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	Process for the preparation of excipient-free agglomerates of beta-lactam antibiotics
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