VERFAHREN ZUR HERSTELLUNG VON NEUEN 2-HALOGEN-NICERGOLINEN
The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), (I) wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyll...
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| creator | KASSAI ANNA SZOMBATHELYI ZSOLT DR LAPIS ERZSEBET MEGYERI GABOR . DR SZPORNY LASZLO DR KARPATI EGON DR TRISCHLER FERENC DR BOGSCH ERIK KEVE TIBOR DR STEFKO BELA DR GALAMBOS JANOS . DR KISS BELA LASZLOVSZKY ISTVAN DR PALOSI EVA DR GROO DORA DR |
| description | The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), (I) wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), (II) wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong alpha -adrenerg blocking and calcium-antagonistic action. |
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DR ; KISS BELA ; LASZLOVSZKY ISTVAN DR ; PALOSI EVA DR ; GROO DORA DR</creator><creatorcontrib>KASSAI ANNA ; SZOMBATHELYI ZSOLT DR ; LAPIS ERZSEBET ; MEGYERI GABOR . DR ; SZPORNY LASZLO DR ; KARPATI EGON DR ; TRISCHLER FERENC DR ; BOGSCH ERIK ; KEVE TIBOR DR ; STEFKO BELA DR ; GALAMBOS JANOS . DR ; KISS BELA ; LASZLOVSZKY ISTVAN DR ; PALOSI EVA DR ; GROO DORA DR</creatorcontrib><description>The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), (I) wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), (II) wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong alpha -adrenerg blocking and calcium-antagonistic action.</description><language>ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1990</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900611&DB=EPODOC&CC=AT&NR=390614B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900611&DB=EPODOC&CC=AT&NR=390614B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KASSAI ANNA</creatorcontrib><creatorcontrib>SZOMBATHELYI ZSOLT DR</creatorcontrib><creatorcontrib>LAPIS ERZSEBET</creatorcontrib><creatorcontrib>MEGYERI GABOR . 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DR</creatorcontrib><creatorcontrib>SZPORNY LASZLO DR</creatorcontrib><creatorcontrib>KARPATI EGON DR</creatorcontrib><creatorcontrib>TRISCHLER FERENC DR</creatorcontrib><creatorcontrib>BOGSCH ERIK</creatorcontrib><creatorcontrib>KEVE TIBOR DR</creatorcontrib><creatorcontrib>STEFKO BELA DR</creatorcontrib><creatorcontrib>GALAMBOS JANOS . DR</creatorcontrib><creatorcontrib>KISS BELA</creatorcontrib><creatorcontrib>LASZLOVSZKY ISTVAN DR</creatorcontrib><creatorcontrib>PALOSI EVA DR</creatorcontrib><creatorcontrib>GROO DORA DR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KASSAI ANNA</au><au>SZOMBATHELYI ZSOLT DR</au><au>LAPIS ERZSEBET</au><au>MEGYERI GABOR . DR</au><au>SZPORNY LASZLO DR</au><au>KARPATI EGON DR</au><au>TRISCHLER FERENC DR</au><au>BOGSCH ERIK</au><au>KEVE TIBOR DR</au><au>STEFKO BELA DR</au><au>GALAMBOS JANOS . DR</au><au>KISS BELA</au><au>LASZLOVSZKY ISTVAN DR</au><au>PALOSI EVA DR</au><au>GROO DORA DR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>VERFAHREN ZUR HERSTELLUNG VON NEUEN 2-HALOGEN-NICERGOLINEN</title><date>1990-06-11</date><risdate>1990</risdate><abstract>The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), (I) wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), (II) wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong alpha -adrenerg blocking and calcium-antagonistic action.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | VERFAHREN ZUR HERSTELLUNG VON NEUEN 2-HALOGEN-NICERGOLINEN |
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