VERFAHREN ZUR HERSTELLUNG VON NEUEN 2-HALOGEN-NICERGOLINEN

The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), (I) wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyll...

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Hauptverfasser:	KASSAI ANNA, SZOMBATHELYI ZSOLT DR, LAPIS ERZSEBET, MEGYERI GABOR . DR, SZPORNY LASZLO DR, KARPATI EGON DR, TRISCHLER FERENC DR, BOGSCH ERIK, KEVE TIBOR DR, STEFKO BELA DR, GALAMBOS JANOS . DR, KISS BELA, LASZLOVSZKY ISTVAN DR, PALOSI EVA DR, GROO DORA DR
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), (I) wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), (II) wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong alpha -adrenerg blocking and calcium-antagonistic action.