VERFAHREN ZUR HERSTELLUNG NEUER INTER-M-PHENYLEN- PROSTACYCLIN-ANALOGA

VERFAHREN ZUR HERSTELLUNG NEUER INTER-M-PHENYLEN- PROSTACYCLIN-ANALOGA

1. Inter-m-phenylene-PGI2 derivatives of general formula I see diagramm : EP0080718,P10,F5 in which R**1 stands for hydrogen, a C1-4 alkyl group, a physiologically acceptable primary, secondary, tertiary or quaternary ammonium cation or a metal cation, R**2 and R**3 stands for hydrogen, R**4 stands...

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Hauptverfasser: KOSZEGI BELA, KOERMOECZY PETER DR, STADLER ISTVAN DR, BOTAR SANDOR, SZEKELY ISTVAN DR, LOVASZ MARIANNA. .DR, TIHANYI KAROLY DR, SZUECS TAMAS DR, HADHAZY PAL DR, DOLGOS KRISZTINA, KOVACS GABOR..DR, VIRAG SANDOR DR, RAKOCZY ISTVAN DR, BLASKO GYOERGY DR
Format: Patent
Sprache:ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:1. Inter-m-phenylene-PGI2 derivatives of general formula I see diagramm : EP0080718,P10,F5 in which R**1 stands for hydrogen, a C1-4 alkyl group, a physiologically acceptable primary, secondary, tertiary or quaternary ammonium cation or a metal cation, R**2 and R**3 stands for hydrogen, R**4 stands for hydrogen or a C1-4 alkyl group, Y stands for -C -= C- or the grouping trans-CH=CW-, in which W = chlorine, bromine or fluorine and Z stands for a C6 -C9 alkyl group optionally substituted once or several times by C1-4 alkyl or fluorine or a phenylmethyl or naphthylmethyl group optionally substituted by phenyl, C1-4 alkyl, C1-4 alkoxy, halogen, trifluoromethyl or nitro, or phenyloxymethyl or naphthoxymethyl group optionally substituted by phenyl, C1-4 alkyl, C1-4 alkoxy, halogen, trifluoromethyl or nitro.