VERFAHREN ZUR HERSTELLUNG VON (E)-5(2-BROMVINYL)- URIDINS UND SEINER DERIVATE

The invention relates to (E)-5-(2-bromovinyl)-uridine and its derivatives of general formula VI, VI wherein R1 stands for a hydrogen atom, C1-8 alkanoyl group, benzoyl group or a benzoyl group substituted in para position either with a C1-4 alkyl group or a halogen atom, and a process for preparing...

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Bibliographische Detailangaben
Hauptverfasser:	IVAN PAL, FRITZSCHE ILDIKO, RETHATI CSILLA, OETVOES LASZLO DR, PEREDY MARIA DR, SAGI JANOS DR, SZEMZOE ATTILA DR, NAGY JANOS, SZABOLCS ANNA DR, HORVATH ISTVAN DR, KOCZKA ISTVAN DR
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The invention relates to (E)-5-(2-bromovinyl)-uridine and its derivatives of general formula VI, VI wherein R1 stands for a hydrogen atom, C1-8 alkanoyl group, benzoyl group or a benzoyl group substituted in para position either with a C1-4 alkyl group or a halogen atom, and a process for preparing them by brominating 2',3',5'-tri-O-acyl-5-ethyl-uridine of general formula IV, IV wherein R is identical with R1, except where R1 stands for a hydrogen atom, dehydrohalogenating the resulting dibromo compound of general formula V V and optionally deacylating it. The resulting compounds of general formula VI are exhibiting significant potency against Herpes simplex virus species and are of remarkably low acute toxicity.