VERFAHREN ZUR HERSTELLUNG VON NEUEN KONDENSIERTEN PYRIMIDIN-4-ON-DERIVATEN UND VON DEREN SALZEN UND OPTISCHEN ANTIPODEN

Geminal dihalogen derivatives of condensed pyrimidine-4-one compounds of the general formula [wherein R represents hydrogen, lower alkyl, or lower alkoxycarbonyl; R represents hydrogen, lower alkyl, ester group, carboxy or a derivative thereof, cyano, phenyl or halogen; R represents hydrogen, lower...

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Hauptverfasser: HERMECZ ISTVAN.. DR, BREINING TIBOR, BITTER ISTVAN.. DR, VASVARI LELLE DR, HORVATH AGNES.. DR, MESZAROS ZOLTAN.. DR, KOEKOESI JOZSEF DR
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Sprache:ger
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Zusammenfassung:Geminal dihalogen derivatives of condensed pyrimidine-4-one compounds of the general formula [wherein R represents hydrogen, lower alkyl, or lower alkoxycarbonyl; R represents hydrogen, lower alkyl, ester group, carboxy or a derivative thereof, cyano, phenyl or halogen; R represents hydrogen, lower alkyl or phenyl; X represents halogen; n is the integer 0, 1 or 2] and the salts and optically active antipodes thereof are of interest as chemical intermediates; some also exhibit a variety of physiological activities and may be formulated into pharmaceutical compositions in conventional manner. The novel compounds can be made by halogenating a corresponding starting material wherein one or both X-substituents are hydrogen.