Novel antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]- benzodiazepines and 6H-pyrrolo[1,2-a][1,4] Benzodiazepines substituted with phenyl derivatives

Novel antifungal 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]- benzodiazepines and 6H-pyrrolo[1,2-a][1,4] Benzodiazepines substituted with phenyl derivatives

The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines of Formula (I) wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MAES LOUISE JULES ROGER MARIE, MEERPOEL LIEVEN, WIT KELLY DE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention is concerned with novel antifungal 5,6-dihydro-4H-pyrrolo-[1,2-a][1,4]benzodiazepines and 6H-pyrrolo[1,2-a][1,4]benzodiazepines of Formula (I) wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.