Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models

Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models

The role of semaphorins in tumor progression is still poorly understood. In this study, we aimed at elucidating the regulatory role of semaphorin 3A (SEMA3A) in primary tumor growth and metastatic dissemination.

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Hauptverfasser: Casazza, Andrea, Fu, Xi, Johansson, Irja, Capparuccia, Lorena, Andersson, Fredrik, Giustacchini, Alice, Squadrito, Mario Leonardo, Venneri, Mary Anna, Mazzone, Massimiliano, Larsson, Erik, Carmeliet, Peter, De Palma, Michele, Naldini, Luigi, Tamagnone, Luca, Rolny, Charlotte
Format: Web Resource
Sprache:eng
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Zusammenfassung:The role of semaphorins in tumor progression is still poorly understood. In this study, we aimed at elucidating the regulatory role of semaphorin 3A (SEMA3A) in primary tumor growth and metastatic dissemination.
DOI:10.1161/ATVBAHA.110.211920