Influence of α-tocopherol on the levels of serum anti-oxLDL antibodies

Purpose - This paper aims to evaluate the association between the α-tocopherol with the levels of serum anti-oxLDL autoantibodies and the risk markers for cardiovascular disease.Design methodology approach - A normolipidemic control group (n=30) and a hypercholesterolemic group (n=33) were used. Plasma lipid profile (colorimetric method), anti-oxLDL autoantibodies (ELISA) and α-tocopherol (HPLC) were analysed.Findings - The α-tocopherol (β=−0.714; p=0.001) is negatively associated with anti-oxLDL autoantibodies in serum and with other risk markers for cardiovascular disease (BMI, WC, total cholesterol, LDL-c) and positively associated with HDL-c.Originality value - Oxidized low density lipoprotein (oxLDL) and their autoantibodies are increased in subjects with hypercholesterolemia. The α-tocopherol can influence the levels of serum anti-oxLDL autoantibodies.