The Emerging Role of PEDF in Stem Cell Biology

The Emerging Role of PEDF in Stem Cell Biology

Encoded by a single gene, PEDF is a 50 kDa glycoprotein that is highly conserved and is widely expressed among many tissues. Most secreted PEDF deposits within the extracellular matrix, with cell-type-specific functions. While traditionally PEDF is known as a strong antiangiogenic factor, more recen...

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Veröffentlicht in:BioMed research international 2012, Vol.2012 (2012), p.1-6
Hauptverfasser: Elahy, Mina, Dass, Crispin R., Baindur-Hudson, Swati
Format: Artikel
Sprache:eng
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Zusammenfassung:Encoded by a single gene, PEDF is a 50 kDa glycoprotein that is highly conserved and is widely expressed among many tissues. Most secreted PEDF deposits within the extracellular matrix, with cell-type-specific functions. While traditionally PEDF is known as a strong antiangiogenic factor, more recently, as this paper highlights, PEDF has been linked with stem cell biology, and there is now accumulating evidence demonstrating the effects of PEDF in a variety of stem cells, mainly in supporting stem cell survival and maintaining multipotency.
ISSN:2314-6133
2314-6141
DOI:10.1155/2012/239091