Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma

Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma

Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity wi...

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Veröffentlicht in:Complexity (New York, N.Y.) N.Y.), 2011, Vol.2011 (2011), p.1-11
Hauptverfasser: Schwentner, Raphaela, Riedmann, Lucia T., Niedan, Stephan, Fourtouna, Argyro, Herrero-Martin, David, Aryee, Dave N. T.
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Sprache:eng
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Zusammenfassung:Ewing's sarcoma family tumors (ESFT) are characterized by specific chromosomal translocations, which give rise to EWS-ETS chimeric proteins. These aberrant transcription factors are the main pathogenic drivers of ESFT. Elucidation of the factors influencing EWS-ETS expression and/or activity will guide the development of novel therapeutic agents against this fatal disease.
ISSN:1076-2787
1099-0526
DOI:10.1155/2011/352580