Synthesis and characterization of heterocyclic compounds derived from 1, 1-bis (4-aminophenyl) cyclohexane and their : study biological activity

Synthesized and characterization of new sulfonamide derivatives ( schiff base , ,azo , azide, chalcone and 1,2,3- triazole) derived from (1, 1- bis (4- aminophenyl) cyclohexane [A1] ). The synthesis compound [A2] include the reaction of compound [A1] with Toluene -4- Sulfonyl chloride while the azo compound [A3] produce from the reaction of diazonium salt with salicylaldehyde , then the azo compound [A3] were converted to chalcone derivative [A4] by reaction the azo compound [A3] with acetophenone . Afterward reflux the azo compound with 2-amino pyrimidine to formation schiff base [A5] . Azide derivative [A6] synthesized via the reaction of diazonium salt with sodium azide . The new 1,2,3- triazole derivatives [A7,A8] were obtained from treatment azide compound[A6] with each ethyl acetoacetate and acetyl acetone ,respectively . The structures of the compounds were confirmed by 1HNMR, 13CNMR, FT-IR spectroscopy and (C.H.N.) elementary analysis. The synthesis compounds were evaluated1 for1antibacterial1(Staphylococcus1aureus , Becillus Cereus, Escherichia1coli, Pseudomonas1aeruginosa1and 1anti-fungal1 (Aspergillus1niger1 and Aspergillus1 fumigatus1by serial dilution1 method.