دراسة انتشار الاتروبين في نظام غشاء سائل باستعمال نموذج حركي جديد

In this study, we place a kinetic model including the diffusion process for transmission of atropine between two benzene phases separated by liquid membrane composed from aqueous solution of copper sulfate, the study included a process of the actual measurement of the kinetics of the process which include the effect of temperature. The operation showed a very good agreement of practical results with the supposed kinetic model. The equilibrium constant of the process (distribution coefficient) tends to make the concentration of atropine in the aqueous phase greater than its concentration in benzene. Kinetic measurements at different temperatures have shown that activation energy for the atropine transport from benzene to aqueous solution is less than those for reverse transmission. This result was interpreting in the light of formation a complex between atropine and copper ion in the aqueous phase and the need of this complex high energy to dissociate to free the atropine and return it to benzene solvent. Thermodynamic functions were extracted using the values of equilibrium constants, where the results showed a decrease in equilibrium constant value with the increase of temperature and the nature of exothermic reaction. The issue of changing the value of diffusion coefficients with temperature was treated according to the holes model, results indicate the rise in the value of diffusion coefficients in both water and benzene with rising temperature in addition to the activation energy required to form holes in the aqueous phase which greater than that of benzene. Also, diffusion activation energy will be much higher than the activation energy for both forward and reverse reactions. Key words: Atropine, kinetic model, diffusion and liquid membranes