Synthesis and X-Ray Crystal Structure of (1E)-1-(4-Chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine

Synthesis and characterization of (1E)-1-(4-chlorophenyl)-N-hydroxy-3-(1H-imidazol-1-yl)propan-1-imine (4) are reported. X-ray crystal structure of the title oxime 4 confirmed its assigned (E)-configuration. The compound crystallizes in the monoclinic space group P21/c with a=13.4292 (3) Å, b=8.8343 (2) Å, c=11.1797 (3) Å, α=90°, β=108.873 (2)°, γ=90°, V=1255.03 (5) Å3, and Z=4. The molecules are packed in crystal structure by weak intermolecular O–H⋯N hydrogen bonding interactions. Compound 4 is a useful intermediate for the synthesis of new imidazole-containing antifungal agents.