Metal- and acid-free, TBN-mediated direct CAH nitration of arenes
A metal-free, acid-free, direct and eco-friendly nitration methodology has been devel oped. A tert-butyl nitrite efficiently promotes the direct C-H nitration of electron-rich arenes with good to excellent yields and regioselectivities. The practical utility of this protocol has been demon strated i...
Gespeichert in:
Veröffentlicht in: | Journal of Saudi Chemical Society 2019, Vol.23 (7), p.896-902 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | A metal-free, acid-free, direct and eco-friendly nitration methodology has been devel oped. A tert-butyl nitrite efficiently promotes the direct C-H nitration of electron-rich arenes with good to excellent yields and regioselectivities. The practical utility of this protocol has been demon strated in gram-scale nitration of crown ether and mono nitration of Sesamin. A plausible free rad ical mechanism is proposed based on detailed experimental observations. |
---|---|
ISSN: | 1319-6103 |
DOI: | 10.1016/j.jscs.2019.01.002 |