254P - Anti-mullerian hormone (AMH) levels and antral follicle counts (AFC) may predict ovarian reserves before systemic chemotherapy (SC) in women with breast cancer (BC): A prospective clinical study

Systemic chemotherapy (SC) has a negative effect on ovarian functions. The aim of this study is to investigate the effect of SC on anti-müllerian hormone (AMH) levels, antral follicle counts (AFC) and ovarian volumes (MOV) in patients with BC. The demographic, clinical and pathological features of premenopausal breast cancer (BC) patients who were operated in the Istanbul Florence Nightingale Hospital were recorded. AMH levels, AFC and MOV measurements were performed before and after adjuvant SC in 3-month periods. The patients who did not have menstruel cycles for 6 months or longer had been classified as chemotherapy induced amenorrhea (CIA). The effects of different chemotherapy regimens on AMH, AFC and MOV in terms menstruel cycles resumption and CIA were investigated. Seventy one patients were eligible for the study, and median age of them was 38 years (ranged from 23 to 51 years). Median follow-up was 37 months (ranged from 20 to 51 months), CIA developed in 62% of patients. AMH, AFC, and MOV significantly decreased one year after SC (p30 ), BMI (30vs> 30), SC regimen and number of cycles (4 vs>4) and CIA (p>0.05).Table254P muitivariet analyses with logistic regrettion for CIATableUNIVARIETMULTIVARIETOR95% CIOR95% CIER0,190,038-0,8910,0350,0020,000- 0,1110,002HER 20.800,435-2,9361,130ALND PERFORMED1,750,653-4,7020,265AMH-10,640,454-0,9140,0140,2730,102- 0,7330,010AMH-50,230,063-0,8120,0230,0090,000- 0,7540,037AFC-10,870,780-0,9610,0070,7350,572- 0,9440,016AFC-50,930,741-1,1650,527MOV-11,000,987-1,0210,686MOV-50,980,854-1,1580,790TAXANE/W&İTHOUTTAXANE0,710,267-1,9100,503TC/AC0,850,209-3,4910,825AGE 354,661,613-13,4980,004CHEMONUMBER0,240,080-0,7660,017BMI 252,570,929-7,1180,069 SC significantly decreases AMH and AFC values independently of chemotherapeutic agents in patients with BC. The low AMH levels and less AFC before SC may predict CIA. İstanbul Demiroğlu Bilim University. Has not received any funding. All authors have de