The Synthesis of Fluorinated 4 H-1,4-Benzothiazine-2-carboxylic Acid 1,1-Dioxides—Thionated Analogues of Pefloxacin

The Synthesis of Fluorinated 4 H-1,4-Benzothiazine-2-carboxylic Acid 1,1-Dioxides—Thionated Analogues of Pefloxacin

A synthetic route to 1,4-benzothiazine-2-carboxylic acid 1,1 -dioxides, analogues of the ‘fluoroquinolone’ family of antibacterials, has been developed; unfortunately, the target compound (the thia-analogue of pefloxacin) has not revealed remarkable antibacterial activity in vitro against the majori...

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Veröffentlicht in:Mendeleev communications 1993, Vol.3 (4), p.159-160
Hauptverfasser: Vysokov, Victor I., Charushin, Valerii N., Afanasyeva, Galina B., Chupakhin, Oleg N.
Format: Artikel
Sprache:eng
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Zusammenfassung:A synthetic route to 1,4-benzothiazine-2-carboxylic acid 1,1 -dioxides, analogues of the ‘fluoroquinolone’ family of antibacterials, has been developed; unfortunately, the target compound (the thia-analogue of pefloxacin) has not revealed remarkable antibacterial activity in vitro against the majority of the strains tested.
ISSN:0959-9436
DOI:10.1070/MC1993v003n04ABEH000267