Preprocedural Serum Atrial Natriuretic Peptide Levels Predict Left Atrial Reverse Remodeling after Catheter Ablation in Patients with Atrial Fibrillation
Abstract Objectives This study aimed to investigate the role of atrial natriuretic peptide (ANP) level to predict left atrial (LA) reverse remodeling in atrial fibrillation (AF) patients. Background Although LA reverse remodeling after radiofrequency catheter ablation (RFCA) for AF was reported to b...
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| creator | Nakanishi, Koki, MD Fukuda, Shota, MD Yamashita, Hajime, MD Kosaka, Michihiko, MD Shirai, Naoya, MD Tanaka, Atsushi, MD Yoshikawa, Junichi, MD Shimada, Kenei, MD |
| description | Abstract Objectives This study aimed to investigate the role of atrial natriuretic peptide (ANP) level to predict left atrial (LA) reverse remodeling in atrial fibrillation (AF) patients. Background Although LA reverse remodeling after radiofrequency catheter ablation (RFCA) for AF was reported to be associated with favorable outcome and following improvement of LA and left ventricular function, the predictor has not been extensively evaluated. Methods This study included 104 consecutive patients undergoing RFCA for AF. All patients underwent multidetector computed tomography examination and laboratory tests including measurement of ANP, plasma B-type natriuretic peptide (BNP), and high-sensitive C-reactive protein (hs-CRP) levels before and 6 months after RFCA. The study population was divided according to the extent of decrease in the LA volume index at follow-up: responders were defined as patients exhibiting a ≥15% decrease in the LA volume index. Results At follow-up, 49 patients (47%) were classified as responders. Preprocedural serum ANP and BNP levels were significantly higher in the responders than in the nonresponders (both p |
| doi_str_mv | 10.1016/j.jacep.2015.12.010 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier</sourceid><recordid>TN_cdi_elsevier_clinicalkeyesjournals_1_s2_0_S2405500X16000049</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S2405500X16000049</els_id><sourcerecordid>1_s2_0_S2405500X16000049</sourcerecordid><originalsourceid>FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S2405500X160000493</originalsourceid><addsrcrecordid>eNqlT0FOwzAQ9AEkKugLuPgDDWuTVHBBqioqDghVLQdukets6AY3idZOEU_ht2wEfQGnmdHM7miUujaQGTDzmyZrnMc-s2CKzNgMDJypic2hmBUAbxdqGmMDIK69syafqO81Y8-dx2pgF_QWeTjoRWIS8eIEB8ZEXq-xT1ShfsYjhqjlqiKfRNbpFN-IxREFD12Fgdp37eqErJcu7XEki11wibpWU6vXwrBNUX9S2p9erGjHFH5DV-q8diHi9A8v1cPq8XX5NJN-PBJy6aWDvAsf-IWx6QZuJVeaMtoSyu04etxs5rIX8vvbfz_4AcoWcwU</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Preprocedural Serum Atrial Natriuretic Peptide Levels Predict Left Atrial Reverse Remodeling after Catheter Ablation in Patients with Atrial Fibrillation</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Nakanishi, Koki, MD ; Fukuda, Shota, MD ; Yamashita, Hajime, MD ; Kosaka, Michihiko, MD ; Shirai, Naoya, MD ; Tanaka, Atsushi, MD ; Yoshikawa, Junichi, MD ; Shimada, Kenei, MD</creator><creatorcontrib>Nakanishi, Koki, MD ; Fukuda, Shota, MD ; Yamashita, Hajime, MD ; Kosaka, Michihiko, MD ; Shirai, Naoya, MD ; Tanaka, Atsushi, MD ; Yoshikawa, Junichi, MD ; Shimada, Kenei, MD</creatorcontrib><description>Abstract Objectives This study aimed to investigate the role of atrial natriuretic peptide (ANP) level to predict left atrial (LA) reverse remodeling in atrial fibrillation (AF) patients. Background Although LA reverse remodeling after radiofrequency catheter ablation (RFCA) for AF was reported to be associated with favorable outcome and following improvement of LA and left ventricular function, the predictor has not been extensively evaluated. Methods This study included 104 consecutive patients undergoing RFCA for AF. All patients underwent multidetector computed tomography examination and laboratory tests including measurement of ANP, plasma B-type natriuretic peptide (BNP), and high-sensitive C-reactive protein (hs-CRP) levels before and 6 months after RFCA. The study population was divided according to the extent of decrease in the LA volume index at follow-up: responders were defined as patients exhibiting a ≥15% decrease in the LA volume index. Results At follow-up, 49 patients (47%) were classified as responders. Preprocedural serum ANP and BNP levels were significantly higher in the responders than in the nonresponders (both p<0.01). In the responders, a significant decrease was observed in the log ANP, log BNP, and log hs-CRP levels from baseline to follow-up (all p<0.01). Multivariate linear regression analysis revealed that log ANP level before RFCA and maintenance of sinus rhythm during follow-up were independent predictors of LA reverse remodeling (both p<0.01). Conclusions In this study, 47% of the patients exhibited LA reverse remodeling after RFCA for AF, with a concomitant improvement in serum ANP, BNP, and hs-CRP levels. The preprocedural ANP level and maintenance of sinus rhythm were independently associated with LA reverse remodeling.</description><identifier>ISSN: 2405-500X</identifier><identifier>DOI: 10.1016/j.jacep.2015.12.010</identifier><language>eng</language><subject>Cardiovascular</subject><ispartof>JACC. Clinical electrophysiology, 2016</ispartof><rights>American College of Cardiology Foundation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Nakanishi, Koki, MD</creatorcontrib><creatorcontrib>Fukuda, Shota, MD</creatorcontrib><creatorcontrib>Yamashita, Hajime, MD</creatorcontrib><creatorcontrib>Kosaka, Michihiko, MD</creatorcontrib><creatorcontrib>Shirai, Naoya, MD</creatorcontrib><creatorcontrib>Tanaka, Atsushi, MD</creatorcontrib><creatorcontrib>Yoshikawa, Junichi, MD</creatorcontrib><creatorcontrib>Shimada, Kenei, MD</creatorcontrib><title>Preprocedural Serum Atrial Natriuretic Peptide Levels Predict Left Atrial Reverse Remodeling after Catheter Ablation in Patients with Atrial Fibrillation</title><title>JACC. Clinical electrophysiology</title><description>Abstract Objectives This study aimed to investigate the role of atrial natriuretic peptide (ANP) level to predict left atrial (LA) reverse remodeling in atrial fibrillation (AF) patients. Background Although LA reverse remodeling after radiofrequency catheter ablation (RFCA) for AF was reported to be associated with favorable outcome and following improvement of LA and left ventricular function, the predictor has not been extensively evaluated. Methods This study included 104 consecutive patients undergoing RFCA for AF. All patients underwent multidetector computed tomography examination and laboratory tests including measurement of ANP, plasma B-type natriuretic peptide (BNP), and high-sensitive C-reactive protein (hs-CRP) levels before and 6 months after RFCA. The study population was divided according to the extent of decrease in the LA volume index at follow-up: responders were defined as patients exhibiting a ≥15% decrease in the LA volume index. Results At follow-up, 49 patients (47%) were classified as responders. Preprocedural serum ANP and BNP levels were significantly higher in the responders than in the nonresponders (both p<0.01). In the responders, a significant decrease was observed in the log ANP, log BNP, and log hs-CRP levels from baseline to follow-up (all p<0.01). Multivariate linear regression analysis revealed that log ANP level before RFCA and maintenance of sinus rhythm during follow-up were independent predictors of LA reverse remodeling (both p<0.01). Conclusions In this study, 47% of the patients exhibited LA reverse remodeling after RFCA for AF, with a concomitant improvement in serum ANP, BNP, and hs-CRP levels. The preprocedural ANP level and maintenance of sinus rhythm were independently associated with LA reverse remodeling.</description><subject>Cardiovascular</subject><issn>2405-500X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqlT0FOwzAQ9AEkKugLuPgDDWuTVHBBqioqDghVLQdukets6AY3idZOEU_ht2wEfQGnmdHM7miUujaQGTDzmyZrnMc-s2CKzNgMDJypic2hmBUAbxdqGmMDIK69syafqO81Y8-dx2pgF_QWeTjoRWIS8eIEB8ZEXq-xT1ShfsYjhqjlqiKfRNbpFN-IxREFD12Fgdp37eqErJcu7XEki11wibpWU6vXwrBNUX9S2p9erGjHFH5DV-q8diHi9A8v1cPq8XX5NJN-PBJy6aWDvAsf-IWx6QZuJVeaMtoSyu04etxs5rIX8vvbfz_4AcoWcwU</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Nakanishi, Koki, MD</creator><creator>Fukuda, Shota, MD</creator><creator>Yamashita, Hajime, MD</creator><creator>Kosaka, Michihiko, MD</creator><creator>Shirai, Naoya, MD</creator><creator>Tanaka, Atsushi, MD</creator><creator>Yoshikawa, Junichi, MD</creator><creator>Shimada, Kenei, MD</creator><scope/></search><sort><creationdate>2016</creationdate><title>Preprocedural Serum Atrial Natriuretic Peptide Levels Predict Left Atrial Reverse Remodeling after Catheter Ablation in Patients with Atrial Fibrillation</title><author>Nakanishi, Koki, MD ; Fukuda, Shota, MD ; Yamashita, Hajime, MD ; Kosaka, Michihiko, MD ; Shirai, Naoya, MD ; Tanaka, Atsushi, MD ; Yoshikawa, Junichi, MD ; Shimada, Kenei, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-elsevier_clinicalkeyesjournals_1_s2_0_S2405500X160000493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cardiovascular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakanishi, Koki, MD</creatorcontrib><creatorcontrib>Fukuda, Shota, MD</creatorcontrib><creatorcontrib>Yamashita, Hajime, MD</creatorcontrib><creatorcontrib>Kosaka, Michihiko, MD</creatorcontrib><creatorcontrib>Shirai, Naoya, MD</creatorcontrib><creatorcontrib>Tanaka, Atsushi, MD</creatorcontrib><creatorcontrib>Yoshikawa, Junichi, MD</creatorcontrib><creatorcontrib>Shimada, Kenei, MD</creatorcontrib><jtitle>JACC. Clinical electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakanishi, Koki, MD</au><au>Fukuda, Shota, MD</au><au>Yamashita, Hajime, MD</au><au>Kosaka, Michihiko, MD</au><au>Shirai, Naoya, MD</au><au>Tanaka, Atsushi, MD</au><au>Yoshikawa, Junichi, MD</au><au>Shimada, Kenei, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preprocedural Serum Atrial Natriuretic Peptide Levels Predict Left Atrial Reverse Remodeling after Catheter Ablation in Patients with Atrial Fibrillation</atitle><jtitle>JACC. Clinical electrophysiology</jtitle><date>2016</date><risdate>2016</risdate><issn>2405-500X</issn><abstract>Abstract Objectives This study aimed to investigate the role of atrial natriuretic peptide (ANP) level to predict left atrial (LA) reverse remodeling in atrial fibrillation (AF) patients. Background Although LA reverse remodeling after radiofrequency catheter ablation (RFCA) for AF was reported to be associated with favorable outcome and following improvement of LA and left ventricular function, the predictor has not been extensively evaluated. Methods This study included 104 consecutive patients undergoing RFCA for AF. All patients underwent multidetector computed tomography examination and laboratory tests including measurement of ANP, plasma B-type natriuretic peptide (BNP), and high-sensitive C-reactive protein (hs-CRP) levels before and 6 months after RFCA. The study population was divided according to the extent of decrease in the LA volume index at follow-up: responders were defined as patients exhibiting a ≥15% decrease in the LA volume index. Results At follow-up, 49 patients (47%) were classified as responders. Preprocedural serum ANP and BNP levels were significantly higher in the responders than in the nonresponders (both p<0.01). In the responders, a significant decrease was observed in the log ANP, log BNP, and log hs-CRP levels from baseline to follow-up (all p<0.01). Multivariate linear regression analysis revealed that log ANP level before RFCA and maintenance of sinus rhythm during follow-up were independent predictors of LA reverse remodeling (both p<0.01). Conclusions In this study, 47% of the patients exhibited LA reverse remodeling after RFCA for AF, with a concomitant improvement in serum ANP, BNP, and hs-CRP levels. The preprocedural ANP level and maintenance of sinus rhythm were independently associated with LA reverse remodeling.</abstract><doi>10.1016/j.jacep.2015.12.010</doi></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Cardiovascular |
| title | Preprocedural Serum Atrial Natriuretic Peptide Levels Predict Left Atrial Reverse Remodeling after Catheter Ablation in Patients with Atrial Fibrillation |
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