Preprocedural Serum Atrial Natriuretic Peptide Levels Predict Left Atrial Reverse Remodeling after Catheter Ablation in Patients with Atrial Fibrillation

Abstract Objectives This study aimed to investigate the role of atrial natriuretic peptide (ANP) level to predict left atrial (LA) reverse remodeling in atrial fibrillation (AF) patients. Background Although LA reverse remodeling after radiofrequency catheter ablation (RFCA) for AF was reported to be associated with favorable outcome and following improvement of LA and left ventricular function, the predictor has not been extensively evaluated. Methods This study included 104 consecutive patients undergoing RFCA for AF. All patients underwent multidetector computed tomography examination and laboratory tests including measurement of ANP, plasma B-type natriuretic peptide (BNP), and high-sensitive C-reactive protein (hs-CRP) levels before and 6 months after RFCA. The study population was divided according to the extent of decrease in the LA volume index at follow-up: responders were defined as patients exhibiting a ≥15% decrease in the LA volume index. Results At follow-up, 49 patients (47%) were classified as responders. Preprocedural serum ANP and BNP levels were significantly higher in the responders than in the nonresponders (both p