5-OR

Objectives The diagnosis acute fatty liver of pregnancy (AFLP) is made by the clinical presentation in combination with the laboratory abnormalities. It is often difficult to distinguish AFLP from HELLP syndrome, a complication of severe preeclampsia. Transient elastography (TE, FibroScan®, EchoSense, Paris) measures tissue elasticity as an indirect parameter for tissue fibrosis, and is frequently used in hepatology for non-invasive assessment of fibrosis. To obtain reference data for TE in hypertensive disorders of pregnancy and AFLP. Methods We conducted a prospective case–control study. Included were patients with severe preeclampsia and HELLP syndrome and AFLP between 24 and 40 weeks of gestational age. A reference group of normotensive pregnant women served as controls. Results We identified 3 cases of AFLP and 25 patients with severe preeclampsia and HELLP syndrome. All cases were matched with normotensive pregnant women. Liver stiffness expressed in kPa was significantly higher in AFLP patients than in patients with severe preeclampsia and HELLP syndrome. Normotensive pregnant women had lower values (See figure). Conclusions Transient elastography of the liver forms a new and discriminating measure to rule out AFLP in hypertensive patients. Disclosures J. Duvekot: None. C. Verveer: None. L. Neven: None. R.D. Man: None. E.A. Steegers: None. H.L. Janssen: None. R.J. Knegt: None.