Role of DNA methylation in bisphenol Aexposed mouse spermatocyte

Role of DNA methylation in bisphenol Aexposed mouse spermatocyte

Highlights • BPA exposure reduced DNA replication capacity and triggered cell apoptosis. • BPA exposure altered the genome-wide DNA methylation level in GC-2 cells. • The expression of mybph and prkcd was regulated by DNA methylation.

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Bibliographische Detailangaben
Veröffentlicht in:Environmental toxicology and pharmacology 2016
Hauptverfasser: Yin, Li, Dai, Yanlin, Xiao, Jiang, Liu, Yong, Chen, Hongqiang, Han, Fei, Cao, Jia, Liu, Jinyi
Format: Artikel
Sprache:eng
Schlagworte:
Emergency
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Zusammenfassung:Highlights • BPA exposure reduced DNA replication capacity and triggered cell apoptosis. • BPA exposure altered the genome-wide DNA methylation level in GC-2 cells. • The expression of mybph and prkcd was regulated by DNA methylation.
ISSN:1382-6689
DOI:10.1016/j.etap.2016.11.003