Diffusion abnormalities of the corpus callosum in patients with malformations of cortical development and epilepsy

Highlights • We investigated diffusion properties of the CC in 32 MCD patients and 32 controls. • Deterministic tractography and ROI-based analyses yielded FA, MD, λ || and λ ⊥. • MCD patients presented significant reductions of FA, increases in MD and λ ⊥. • No differences between MCD subgroups, and no correlations with clinical parameters. • MCD patients present widespread changes that extend beyond the macroscopic lesions.