Preconditioning of H2 S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathway

Preconditioning of H2 S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathway

Highlights • H2 S preconditioning exhibited significant neuroprotection against cerebral I/R. • The protective effect of H2 S preconditioning involves heat shock protein 70 (HSP70). • HSP70 protects mice against cerebral I/R through PI3K/Akt/Nrf2 pathway.

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Bibliographische Detailangaben
Veröffentlicht in:Brain research bulletin 2016, Vol.121, p.68-74
Hauptverfasser: Ji, Kangxiang, Xue, Long, Cheng, Jiwei, Bai, Yu
Format: Artikel
Sprache:eng
Schlagworte:
Neurology
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Zusammenfassung:Highlights • H2 S preconditioning exhibited significant neuroprotection against cerebral I/R. • The protective effect of H2 S preconditioning involves heat shock protein 70 (HSP70). • HSP70 protects mice against cerebral I/R through PI3K/Akt/Nrf2 pathway.
ISSN:0361-9230
DOI:10.1016/j.brainresbull.2015.12.007