Polyunsaturated Fatty Acid Status, Phospholipase A2 Activity and Brain White Matter Microstructure in Late Childhood and Adolescence

Polyunsaturated Fatty Acid Status, Phospholipase A2 Activity and Brain White Matter Microstructure in Late Childhood and Adolescence

Highlights • Physiological phospholipase A2 activity levels are associated with brain white matter microstructure in adolescence. • Membrane docosahexaenoic acid concentration is associated with white matter microstructure in adolescence. • White matter development may involve cleavage of docosahexa...

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Veröffentlicht in:Neuroscience 2016
Hauptverfasser: McNamara, Robert K, Szeszko, Philip R, Smesny, Stefan, Ikuta, Toshikazu, DeRosse, Pamela, Vaz, Frédéric M, Milleit, Berko, Hipler, Uta-Christina, Wiegand, Cornelia, Hesse, Jana, Paul Amminger, G, Malhotra, Anil K, Peters, Bart D
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Sprache:eng
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Neurology
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Zusammenfassung:Highlights • Physiological phospholipase A2 activity levels are associated with brain white matter microstructure in adolescence. • Membrane docosahexaenoic acid concentration is associated with white matter microstructure in adolescence. • White matter development may involve cleavage of docosahexaenoic acid from membrane phospholipids by phospholipase A2. • Docosahexaenoic acid and phospholipase A2 may be implicated in myelin-related neurodevelopmental disorders.
ISSN:0306-4522
DOI:10.1016/j.neuroscience.2016.12.007