α4βδ-GABAA Rs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia

α4βδ-GABAA Rs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia

Highlights • Food restriction (FR) upon adolescent female rats evokes robust wheel running. • Individual differences in activity exist pre-FR and correlate with post-FR activity. • α4-GABAA R levels at hippocampal spines are increased by FR. • α4 levels in CA1 spines are higher in animals with minim...

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Veröffentlicht in:Neuroscience 2014, Vol.265, p.108-123
Hauptverfasser: Aoki, C, Wable, G, Chowdhury, T.G, Sabaliauskas, N.A, Laurino, K, Barbarich-Marsteller, N.C
Format: Artikel
Sprache:eng
Schlagworte:
Neurology
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Zusammenfassung:Highlights • Food restriction (FR) upon adolescent female rats evokes robust wheel running. • Individual differences in activity exist pre-FR and correlate with post-FR activity. • α4-GABAA R levels at hippocampal spines are increased by FR. • α4 levels in CA1 spines are higher in animals with minimal pre- and post-FR activity. • α4 in CA1 spines are strongly correlated to weight loss ( R = −0.9).
ISSN:0306-4522
DOI:10.1016/j.neuroscience.2014.01.011