Evaluation of humoral and cellular immune response of BALB/c mice immunized with a recombinant fragment of MSP1 a from Anaplasma marginale using carbon nanotubes as a carrier molecule

Evaluation of humoral and cellular immune response of BALB/c mice immunized with a recombinant fragment of MSP1 a from Anaplasma marginale using carbon nanotubes as a carrier molecule

Highlights • rMSP1 a was efficiently linked to multiwalled carbon nanotubes (MWNT). • The immunization with rMSP1a and MWNT + rMSP1 a induced higher antibody levels. • Mice immunizated with MWNT + rMSP1 a showed higher T cell proliferation rates. • MWNT + rMSP1a induced higher percentage of TNFα, CD...

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Veröffentlicht in:Vaccine 2014-04, Vol.32 (19), p.2160-2166
Hauptverfasser: Silvestre, Bruna T, Rabelo, Élida M.L, Versiani, Alice F, da Fonseca, Flávio G, Silveira, Júlia A.G, Bueno, Lilian L, Fujiwara, Ricardo T, Ribeiro, Múcio F.B
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
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Zusammenfassung:Highlights • rMSP1 a was efficiently linked to multiwalled carbon nanotubes (MWNT). • The immunization with rMSP1a and MWNT + rMSP1 a induced higher antibody levels. • Mice immunizated with MWNT + rMSP1 a showed higher T cell proliferation rates. • MWNT + rMSP1a induced higher percentage of TNFα, CD4+ CD44+ and CD4+ CD62L+ lymphocytes.
ISSN:0264-410X
DOI:10.1016/j.vaccine.2014.02.062