ER2, a novel human anti-EGFR monoclonal antibodyinhibit tumor activity innon-small cell lung cancer models
Highlights • ER2 suppressed EGFR pathway and induced G1 arrest and apoptosis in NSCLC cells. • ER2 inhibited EGF-stimulated VEGF production. • ER2 induced anti-tumor activity in combination with cisplatin in xenograft models.
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Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2016 |
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Hauptverfasser: | , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Highlights • ER2 suppressed EGFR pathway and induced G1 arrest and apoptosis in NSCLC cells. • ER2 inhibited EGF-stimulated VEGF production. • ER2 induced anti-tumor activity in combination with cisplatin in xenograft models. |
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ISSN: | 0169-5002 |
DOI: | 10.1016/j.lungcan.2016.02.013 |