Primary myelofibrosis: older age and high JAK2 V617F allele burden are associated with elevated plasma high-sensitivity C-reactive protein levels and a phenotype of progressive disease

Highlights • We have measured plasma levels of hs-CRP in 526 subjects with PMF. • 38% of subjects with PMF had elevated hs-CRP. • Age ≥ 52 years and JAK2 V617F mutation with ≥ 50% allele burden were independently associated with elevated hs-CRP. • Older age and high allele burden JAK2 V617F mutation were also associated with a phenotype of progressive disease. • We interpreted our finding as reflecting an intrinsic inflammatory pathway promoted by older age and high allele burden JAK2 V617F