Cardiac and Skeletal Muscles Metastases From Squamous Cell Carcinoma of the Bladder: PET/CT Findings

Abstract We describe the PET/CT findings of a patient who underwent a radical cystectomy six months earlier because of a squamous cell carcinoma of the bladder (SCCB) that presented to the ER with chest pain and palpitations. Cardiac catheterization ruled out coronary artery occlusion, but PET/CT showed multiple FDG-avid lesions involving multiple skeletal muscles and the heart, consistent with metastases. A CT-guided biopsy of one skeletal muscle lesion confirmed a metastasis with the same pathologic features as the SCCB. To our knowledge, this is the first reported case of a SCCB with metastases to multiple skeletal muscles and myocardium detected with PET/CT.