Baicalein enhances the osteogenic differentiation of human periodontal ligament cells by activating the Wnt/β-cateninsignaling pathway

Baicalein enhances the osteogenic differentiation of human periodontal ligament cells by activating the Wnt/β-cateninsignaling pathway

Highlights • Baicalein enhanced the osteogenic differentiation of hPDLCs. • The optimal dosage of baicalein was 10 μM. • DKK-1 significantly reversed the effects of baicalein on hPDLCs. • The effects are exerted by activating the Wnt/β-catenin signaling pathway.

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Veröffentlicht in:Archives of oral biology 2017
Hauptverfasser: Chen, Li-Jiao, Hu, Bi-Bo, Shi, Xin-Lian, Ren, Man-Man, Yu, Wen-Bin, Cen, Sheng-Dan, Hu, Rong-Dang, Deng, Hui
Format: Artikel
Sprache:eng
Schlagworte:
Advanced Basic Science
Dentistry
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Zusammenfassung:Highlights • Baicalein enhanced the osteogenic differentiation of hPDLCs. • The optimal dosage of baicalein was 10 μM. • DKK-1 significantly reversed the effects of baicalein on hPDLCs. • The effects are exerted by activating the Wnt/β-catenin signaling pathway.
ISSN:0003-9969
DOI:10.1016/j.archoralbio.2017.01.019