Outcomes of percutaneous closure of patent ductus arteriosus acommpanied with unilateral absence of pulmonary artery

Abstract Background Limited data reported the outcomes of percutaneous closure of patent ductus arteriosus (PDA) in patients with unilateral absence of pulmonary artery (UAPA). This study aimed to evaluate the symptomatology, diagnosis and therapy, especially the transcatheter clousre of PDA in patients with PDA associated with UAPA. Methods Patients diagnosed with PDA and UAPA were retrospectively enrolled from August 2010 through January 2016. Clinical data, treatment and follow-up information were evaluated. Results 13 patients (6 males and 7 females) were diagnosed with PDA associated with UAPA. Percutaneous closure was conducted in 6 patients successfully. The median age was 7 years (7 months to 37 years). The mean diameter of the PDA and occluders were 4.7±1.8 mm (2–7 mm), 11.3±3.9 mm (6–14 mm) respectively. The mean pulmonary artery pressure was 41.5±13.5 mmHg （25–62 mmHg). The diameter of PDA has no relationship with the degree of pulmonary artery pressure (r=0.239, p = 0.648). In 4 patients, systolic pulmonary arterial pressure decreased significantly after closure 69.0±10.7 v 48.0±11.3 mmHg (p = 0.146), and also the mean pulmonary arterial pressure 54.5±5.7 v 30.5±3.9 mmHg (p = 0.04). 1 patient had trace residual shunt which disappeard within 24 hours. Conclusions In appropriate patients with PDA associated with UAPA, transcatheter closure of PDA has the potential to improve the pulmonary artery hypertension. Further follow-up is required to monitor the long-term outcomes.