Prognostic Significance of Early Rehospitalization Following Takotsubo Cardiomyopathy

Abstract Short-term complications, particularly rehospitalization, following a diagnosis of Takotsubo Cardiomyopathy (TTC) are poorly described. We sought to characterize the rates, causes, clinical associations, and prognostic implications of early rehospitalization in this patient population. We performed a retrospective observational study of all adult subjects diagnosed with TTC at an academic tertiary care hospital between 2005 and 2015. The primary outcome was rehospitalization within 30 days of index discharge. Multivariable logistic regression was used to test for association between clinical variables and rehospitalization. Association between rehospitalization and survival following index discharge was assessed as a secondary outcome using a multivariable Cox proportional hazard model. Two hundred and sixty-three subjects met the inclusion criteria for the study. There were 38 rehospitalizations among 32 (12%) subjects. Ninety-five percent of rehospitalizations were due to non-heart failure causes and 76% were related to non-cardiovascular complaints. In multivariable analysis, recent hospitalization prior to TTC diagnosis and increased length of index hospitalization were associated with greater risk of rehospitalization (OR=4.58,95% CI=1.97 to 10.65, p