Development of Peptidomimetic Inhibitors of a Newly Isolated Atrial Peptide-Degrading Enzyme
Toll et al. recently reported the isolation of a new atrial peptide-degrading enzyme (ADE) from bovine kidney that preferentially cleaves atrial peptide substrates at their Ser-Phe bond. ADE is inhibited by general protease inhibitors that inhibit either metallo or cysteine proteases. However, it is...
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